5. Lipinski
نویسندگان
چکیده
Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all ‘chemical space’ is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?
منابع مشابه
Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability
Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration (Lipinski 1995; Lipinski 2000; Lipinski et al. 2001; Lipinski 2004; Abrahamsson and Lennernas 2005). Thus, oral bioavailability is one of the key considerations for discovery and development of a new chemical entity (NCE). It is well recog...
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R. Lipinski, C. Song, J. Gipp, W. Bushman, and I. Rowland Bowles Center for Alcohol Research, University of North Carolina, Chapel Hill, North Carolina, United States, Medical Physics, University of Wisconsin, Madison, Wisconsin, United States, Urology Department, University of Wisconsin, Madison, Wisconsin, United States, Department of Radiology, University of Wisconsin, Madison, Wisconsin, Un...
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Marie Lebeau ([email protected]) Simone Mathoulin-Pelissier ([email protected]) Carine Bellera ([email protected]) Christine Tunon de Lara ([email protected]) Alain Daban ([email protected]) Francis Lipinski ([email protected]) Dominique Jaubert ([email protected]) Pierre Ingrand ([email protected]) Virginie Migeot (v.migeot@chu-...
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Cyclophilin D (CypD) is a peptidyl prolyl isomerase F that resides in the mitochondrial matrix and associates with the inner mitochondrial membrane during the mitochondrial membrane permeability transition. CypD plays a central role in opening the mitochondrial membrane permeability transition pore (mPTP) leading to cell death and has been linked to Alzheimer's disease (AD). Because CypD intera...
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A Plawski, J Lubiński, T Banasiewicz, J Paszkowski, D Lipinski, A Strembalska, G Kurzawski, T Byrski, S Zajaczek, D Hodorowicz-Zaniewska, T Gach, I Brozek, D Nowakowska, E Czkwaniec, P Krokowicz, M Drews, J Zeyland, W Juzwa, R Słomski . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
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